The Science
Collagen is a key structural protein that helps maintain our skin, bones, and joints. Collagen production declines with age and can show up as wrinkles, joint pain, decreased bone density, and slower wound healing.* Collagen’s crucial role in the body’s strength, structure, and support make it a trending ingredient for research in the nutraceutical space.*
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PÅ«rColla® sets itself apart from competitors, starting with clean, fresh sourcing. Rather than relying on harsh chemicals and additives, our natural bio-fermentation process yields a clean, pure bioactive collagen. Its small molecular weight makes it more readily absorbed by the body, and may help maximize its bioavailability and potential benefits.* The white papers below explore collagen’s role in satiety, skin health, collagen synthesis, bone health, and recovery.
Collagen Research
Emerging research indicates that hydrolyzed, bioactive collagen peptides may resist complete breakdown during digestion, entering the circulation as intact bioavailable sequences. These fragments are thought to act as cellular messengers, supporting the body’s natural systemic functions, including immune health, antioxidant activity, and the maintenance of healthy vascular and structural tissues.*
References
1. Balshaw, T. G., Funnell, M. P., McDermott, E., Maden-Wilkinson, T. M., Abela, S., Quteishat, B., Edsey, M., James, L. J., & Folland, J. P. (2023). The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training. Acta physiologica (Oxford, England), 237(2), e13903. https://doi.org/10.1111/apha.13903
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2. Inacio, P. A. Q., Chaluppe, F. A., Aguiar, G. F., Coelho, C. d. F., & Vieira, R. P. (2024). Effects of hydrolyzed collagen as a dietary supplement on fibroblast activation: A systematic review. Nutrients, 16(11), 1543. https://doi.org/10.3390/nu16111543
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3. Lin, C.-R., Tsai, S. H. L., Huang, K.-Y., Tsai, P.-A., Chou, H., & Chang, S.-H. (2023). Analgesic efficacy of collagen peptide in knee osteoarthritis: A meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research, 18, 694. https://doi.org/10.1186/s13018-023-04182-w
4. Liu, J., Wang, Y., Song, S., Wang, X., Qin, Y., & Si, S. (2015). Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PLoS ONE, 10(8), e0135019. https://doi.org/10.1371/journal.pone.0135019
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5. López-Yoldi, M., Riezu-Boj, J. I., Abete, I., Ibero-Baraibar, I., Aranaz, P., González-Salazar, I., Izco, J. M., Recalde, J. I., González-Navarro, C. J., Milagro, F. I., et al. (2024). Anti-obesity effects of a collagen with low digestibility and high swelling capacity: A human randomized control trial. Nutrients, 16(20), 3550. https://doi.org/10.3390/nu16203550
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6. Khatri, M., Naughton, R. J., Clifford, T., Harper, L. D., & Corr, L. (2023). The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: A systematic review. British Journal of Nutrition, 129(5), 779–794. https://doi.org/10.1007/s00726-021-03072-x
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7. König, D., Oesser, S., Scharla, S., Zdzieblik, D., & Gollhofer, A. (2018). Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients, 10(1), 97. https://doi.org/10.3390/nu10010097
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8. Jalili, Z., Jalili, F., Moradi, S., Bagheri, R., Moosavian, S. P., Naeini, F., Mohammadi, H., Ghoreishy, S. M., Wong, A., Travica, N., Hojjati Kermani, M. A., & Jalili, C. (2023). Effects of collagen peptide supplementation on cardiovascular markers: A systematic review and meta-analysis of randomised, placebo-controlled trials. Amino Acids, 53, 1493–1506. https://doi.org/10.1017/S0007114522001301
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9. Song, H., Zhang, S., Zhang, L., & Li, B. (2017). Effect of orally administered collagen peptides from bovine bone on skin aging in chronologically aged mice. Nutrients, 9(11), 1209. https://doi.org/10.3390/nu9111209